Basic Information
VIS ID
TVIS44012284
Fusion event
HTLV-1-MAPRE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
32569910/34989946 (Hg38)
End
32569910/34989946 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
MAPRE2
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-455-3p ; hsa-mir-432-3p ; hsa-mir-297 ; hsa-mir-3171 ; hsa-mir-4480 ; hsa-mir-4501 ; hsa-mir-377-5p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-192-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-567 ; hsa-mir-4764-5p ; hsa-mir-4725-5p ; hsa-mir-4670-3p ; hsa-mir-216a-5p ; hsa-mir-3074-5p ; hsa-mir-3140-3p ; hsa-mir-370-3p ; hsa-mir-6893-3p ; hsa-mir-7152-5p
Nearest miRNA
hsa-mir-1-2/Upstream/4690986; hsa-mir-122/Downstream/601791;
Nearest TSS
ENST00000575820/Upstream/11520; ENST00000585592/Downstream/51414;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/12027, chr18-CpG: 46/Downstream/51305
Upstream sequence
cccggtaatctgttgtttggcattaatatttgagaaacattgATATGGAAAGCCTTTCCTAACCTCCTAACCATGGTCTCCACCCATCTCAATGGGGTGA
Downstream sequence
GTTAGGTGGCCCATATTTGGTTTGCTTTTCATCCCCCTTGCATGGCAATCCATTGAAGATTGCAATAAACtttcattcatttccacatccccagattcta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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