Basic Information
VIS ID
TVIS44012292
Fusion event
HTLV-1-GALNT5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
158134734/157278222 (Hg38)
End
158134734/157278222 (Hg38)
Orient
+
Location type
Intronic
Target gene
GALNT5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3148 ; hsa-mir-651-3p ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-128-1/Upstream/5909811; hsa-mir-10b/Downstream/1908613;
Nearest TSS
ENST00000437798/Upstream/20624; ENST00000463418/Downstream/22581;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/841725, chr2-CpG: 31/Downstream/319065
Upstream sequence
tttctttaagaatgttgaattttggccctcactctcgtctggcttgtagagtttctgccgagagatccaccattagtctgatcggcttccctttgtgggt
Downstream sequence
aagccaacctttctatctggctgtccttaacatttttcccttcatttcaactttggtgaatctgaaaattatgtgtcttggagttgctcttctcatggag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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