Basic Information
VIS ID
TVIS44012294
Fusion event
HTLV-1-CBFA2T2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
32149523/33561717 (Hg38)
End
32149523/33561717 (Hg38)
Orient
+
Location type
Intronic
Target gene
CBFA2T2
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-7977 ; hsa-mir-7160-5p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-1273g-3p ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3202 ; hsa-mir-3714 ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4257 ; hsa-mir-4533 ; hsa-mir-455-3p ; hsa-mir-490-3p ; hsa-mir-5694 ; hsa-mir-605-3p ; hsa-mir-6086 ; hsa-mir-619-3p ; hsa-mir-6499-3p ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6807-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1323870; hsa-mir-1-1/Downstream/487402;
Nearest TSS
ENST00000382410/Upstream/71600; ENST00000344201/Downstream/617;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/71054, chr20-CpG: 17/Downstream/82647
Upstream sequence
TCTGTCATCTCTCTGGATTTTCATTGTTATTGTTCTTAAAATATTTTTTATTTTGGCGACTCATTGTTGACACTTATATTAGCAGTTATTTTAATGTTAA
Downstream sequence
ATATTATGTTATTTCTGACATTTATATTTGCTCTGTTTTAAAACAATTTTGCATTGTGTCCCCATCTTCCATTTATAATCTTTACAGCATCAGAACCATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate