Basic Information
VIS ID
TVIS44012303
Fusion event
HTLV-1-GRK7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
141490526/141771684 (Hg38)
End
141490526/141771684 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRK7
miRNAs that regulate target gene
hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6807-5p ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-219b-3p ; hsa-mir-6128 ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-let-7g/Upstream/7333778; hsa-mir-1224/Downstream/9794192;
Nearest TSS
ENST00000440867/Upstream/25842; ENST00000264952/Downstream/6464;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/33016, chr3-CpG: 27/Downstream/6632
Nearby gene
GRK7(+6517) ;
Upstream sequence
aatgtgtacaatgtacattattcaagtgatggctacactaaacgcctagacttcatcattatgtaatatagccatataacaaaactgtgcttgtacctcc
Downstream sequence
caaatctattttttttttgagactgagtgttgctttgtcacccaggctggagagcagtggcgcaatctaggctcactgtaacctctgcctcctgggttca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate