Basic Information
VIS ID
TVIS44012315
Fusion event
HTLV-1-NREP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
111213316/111877619 (Hg38)
End
111213316/111877619 (Hg38)
Orient
-
Location type
Intronic
Target gene
NREP
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-29b-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3613-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/1363704; hsa-mir-103a-1/Downstream/4378124;
Nearest TSS
ENST00000502646/Upstream/119401; ENST00000508389/Downstream/34889;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/119402, chr5-CpG: 51/Downstream/283091
Upstream sequence
AGTTGGTTGTGTTAGTTAATCTGCTTTTGTAACCATGTGACAGAAACCAGCATGAACTGGGCAAATGGAAATGAAAATCTTATGTGCAATAATACTCAAA
Downstream sequence
TATTTTACAAAACTCAGCCTTAAAGAAGCAACTGGACATGAGACAATTTGAACACTGTTTGGAATCTCCCATTCCTAAGCTTTGTTCCATTTATCACTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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