Basic Information
VIS ID
TVIS44012320
Fusion event
HTLV-1-DST integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
56462605/56597807 (Hg38)
End
56462605/56597807 (Hg38)
Orient
+
Location type
Exonic
Target gene
DST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-218-5p ; hsa-mir-26a-5p ; hsa-mir-3130-3p ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-136-5p ; hsa-mir-127-5p ; hsa-mir-432-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-500a-3p ; hsa-mir-6882-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-6804-3p ; hsa-mir-1468-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-545-3p ; hsa-mir-8063 ; hsa-mir-548p ; hsa-mir-4460 ; hsa-mir-4662a-5p ; hsa-mir-3119 ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-553
Nearest miRNA
hsa-mir-10398/Upstream/3320736; hsa-mir-10524/Downstream/792325;
Nearest TSS
ENST00000381078/Upstream/37365; ENST00000426453/Downstream/706;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/54679, chr6-CpG: 107/Downstream/245454
Upstream sequence
TTGAACGATATCATATGTTTATAACAACACACCTTAACTTTCTGATATTGCTGATTCAGATTCTCCTGAGTGGTTCCAACTTGCCCATCAACATCAGTCT
Downstream sequence
CCAACAGGTTACCATTAACTTCATCCTCTTCTCCAATTGCTGACTTGCCATCACCTTCTTGAAAATGGGTCCCGTTCTGTTCGATTACCTGTTTGTGTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate