Basic Information
VIS ID
TVIS44012348
Fusion event
HTLV-1-OGG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
9792802/9751118 (Hg38)
End
9792802/9751118 (Hg38)
Orient
-
Location type
Exonic
Target gene
OGG1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-1260b ; hsa-mir-6824-5p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5092 ; hsa-mir-1178-5p ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-4790/Upstream/4500863; hsa-let-7g/Downstream/529233;
Nearest TSS
ENST00000440867/Upstream/26; ENST00000383825/Downstream/785;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/791, chr3-CpG: 86/Downstream/41190
Upstream sequence
AGCAGCTCCACTGCACTGTGTACCGAGGAGACAAGAGCCAGGCTAGCAGGCCCACACCAGACGAGCTGGAGGCCGTGCGCAAGTACTTCCAGCTAGATGT
Downstream sequence
TACCCTGGCTCAACTGTATCACCACTGGGGTTCCGTGGACTCCCACTTCCAAGAGGTGGCTCAGAAATTCCAAGGTGAGTACAGGACCTGGGCTGGGGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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