Basic Information
VIS ID
TVIS44012361
Fusion event
HTLV-1-GSE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85681599/85647993 (Hg38)
End
85681599/85647993 (Hg38)
Orient
+
Location type
Intronic
Target gene
GSE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-331-3p ; hsa-mir-361-3p ; hsa-mir-324-3p ; hsa-mir-759 ; hsa-mir-1913 ; hsa-mir-5586-3p ; hsa-mir-548av-3p ; hsa-mir-513a-5p ; hsa-mir-5687 ; hsa-mir-4775 ; hsa-mir-4313 ; hsa-mir-1236-5p ; hsa-mir-29c-5p ; hsa-mir-4773 ; hsa-mir-548g-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-489-3p
Nearest miRNA
hsa-mir-12128/Upstream/341668; hsa-mir-11401/Downstream/93628;
Nearest TSS
ENST00000527434/Upstream/34641; ENST00000479488/Downstream/6439;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5007, chr16-CpG: 33/Downstream/2508
Upstream sequence
CGCTTCTTGTGTTTGTTCCCTGCTGCACTGCAGCCCCATGTCTGCCCTGCTTGATGGGAGCCCCCGGAGGGGGCGCCTTTTCCTGTGACCCCCCAAGCAC
Downstream sequence
ATGGGGGCTCCCCGGGAAGACTCAGAGGCTTGGGGTCTCTGCTGCTTACACGTGGAGCTGCCTCTCGGTGGGGCAGGGTGTGTGGCCCAGCTGGCCTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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