Basic Information
VIS ID
TVIS44012382
Fusion event
HTLV-1-INSIG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
118853531/118095955 (Hg38)
End
118853531/118095955 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
INSIG2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-142-3p ; hsa-mir-190a-3p ; hsa-mir-4517 ; hsa-mir-5011-5p ; hsa-mir-5583-3p ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-6516-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-455-3p ; hsa-mir-7151-5p ; hsa-mir-335-3p ; hsa-mir-2110 ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-6852-5p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-2115-3p ; hsa-mir-7851-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4374587; hsa-mir-10b/Downstream/9327582;
Nearest TSS
ENST00000437798/Upstream/7405; ENST00000488995/Downstream/463;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/7361, chr2-CpG: 41/Downstream/90292
Upstream sequence
GGTCTGGTTTTGTAGAATGTTTTTGTGCGGATAACCAAATAATAAACATTAAAGCGGGTTATTTTGTTCTTCTGTGGAGGTTGTCCTTGTAAGCAAGTAA
Downstream sequence
CATTTTATTGCAAAATATACAGCGTCTTCAGTCAGAATATGCTTATCTGTAAAATATAAAATACAGTATTGTAACTGATAGGCTTAGAGATTTAGGGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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