Basic Information
VIS ID
TVIS44012389
Fusion event
HTLV-1-ACTR3C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
149610934/149913845 (Hg38)
End
149610934/149913845 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ACTR3C
miRNAs that regulate target gene
hsa-mir-379-3p ; hsa-mir-487a-3p ; hsa-mir-127-3p ; hsa-mir-539-3p
Nearest miRNA
hsa-mir-10399/Upstream/2535724; hsa-mir-153-2/Downstream/1324576;
Nearest TSS
ENST00000635602/Upstream/23106; ENST00000565102/Downstream/86907;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/39545, chr7-CpG: 189/Downstream/133468
Nearby gene
ATP6V0E2(+33133) ;
Upstream sequence
TAGCATTTTTATATAATGCAAGCTTCCTCACTGTCACATTATACCACAACCTTCTTCCACCCACCACATTTAGCACGATATATCTATAATACTGAAGTTT
Downstream sequence
AATACTGGTCAGAAGTTCAGAAGAAATAACTCATATGTCCCtttttttttttttttttttgagacagtctcactctgtcacccaagctggagtacagtgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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