Basic Information
VIS ID
TVIS44012405
Fusion event
HTLV-1-LARGE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
33931651/33535665 (Hg38)
End
33931651/33535665 (Hg38)
Orient
+
Location type
Intronic
Target gene
LARGE1
miRNAs that regulate target gene
hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1286/Upstream/98996; hsa-let-7a-3/Downstream/1799975;
Nearest TSS
ENST00000624155/Upstream/151438; ENST00000610170/Downstream/29354;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/477197, chr22-CpG: 20/Downstream/114703
Upstream sequence
aaaatgcagcaatatgcagggaccaaagaggaatatctccctggctgtataaactggagaagaggtaggggttctaactatttcttatacaaactattga
Downstream sequence
ccaaccccctcatagggctggggatccattccatgtggcatttgggaatacctggaacctctcacggctgagccctgtctgggatcagcaaagtcaatca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate