Basic Information
VIS ID
TVIS44012409
Fusion event
HTLV-1-KCNH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
211087109/210913767 (Hg38)
End
211087109/210913767 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCNH1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-2467-3p ; hsa-mir-4257 ; hsa-mir-6890-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-505-3p ; hsa-mir-4290 ; hsa-mir-1233-3p ; hsa-mir-7113-3p ; hsa-mir-4673 ; hsa-mir-339-5p ; hsa-mir-4645-5p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4687-5p ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1290257; hsa-mir-1182/Downstream/1163846;
Nearest TSS
ENST00000473358/Upstream/229838; ENST00000472734/Downstream/105423;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/229847, chr1-CpG: 92/Downstream/219558
Upstream sequence
GAGGACTAATGTTTCCTAGTATCAACTGACGGAATAAGACTATGGGGAGAAGAAGGAAAGTtgaggctgacactactggtcatccccccatatcagtttt
Downstream sequence
ccttgcatatattaccgtatttctactcaggcacatgaccactcagaataaatactatatttctatatttccaagcttcccttcccagtgtggctaggtt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate