Basic Information
VIS ID
TVIS44012411
Fusion event
HTLV-1-ARHGAP22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
49749905/48541860 (Hg38)
End
49749905/48541860 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ARHGAP22
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-615-3p ; hsa-mir-421 ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-4709-5p ; hsa-mir-1178-5p ; hsa-mir-5580-5p ; hsa-mir-202-3p ; hsa-mir-149-5p ; hsa-mir-4267 ; hsa-mir-1207-3p
Nearest miRNA
hsa-mir-1265/Upstream/3377772; hsa-mir-107/Downstream/443652;
Nearest TSS
ENST00000439456/Upstream/17624; ENST00000360890/Downstream/14818;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/17267, chr10-CpG: 40/Downstream/62947
Upstream sequence
ACCTTCCAGTTGGCATCATTCAAGAGATGTGGCTGAAGTTTGATCACCTAATTGGGACCCTGGCCTCGATCTGCAAGGATGAAGGTGCAGGCCACCCTCC
Downstream sequence
AAGGGTGACATTACCTATTGAGCTCCATGGGGGGAGTTCAGTTAAAGGCCCCTTTGCCGTATTGGATCAGGAAGAGCCACCTGTGAAGTGTATGCTGGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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