Basic Information
VIS ID
TVIS44012417
Fusion event
HTLV-1-TRIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154073912/153152760 (Hg38)
End
154073912/153152760 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRIM2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-181c-5p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-181a-5p ; hsa-mir-10a-5p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-186-5p ; hsa-mir-10b-5p ; hsa-mir-3190-3p ; hsa-mir-493-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5690 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-410-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-6079 ; hsa-mir-411-5p ; hsa-mir-3117-3p ; hsa-mir-1258 ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-3681-5p ; hsa-mir-6849-5p ; hsa-mir-1244 ; hsa-mir-1197 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-12113/Upstream/616244; hsa-mir-1305/Downstream/5976042;
Nearest TSS
ENST00000502981/Upstream/267; ENST00000496978/Downstream/358;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/176163, chr4-CpG: 71/Downstream/471
Nearby gene
TRIM2(+358) ;
Upstream sequence
CGCGCGACTGAAACGGGAGCAGAGCAGTTGAATGAGCTTCTTACGCTTTGCATGGTGCGCAGAATATCCCACCGATACCCAGAAATCCAGTAGAAATAGG
Downstream sequence
GACGAGTGTTGCTGCGAAAGAGCCTTTTGCATTTGAAATGCATGTTAGGTTAACTGGAAAGGCGCCTGCCTCTTGTTTTGTTTCAGAAATACTGTTGGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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