Basic Information
VIS ID
TVIS44012423
Fusion event
HTLV-1-DUSP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
221907282/221733940 (Hg38)
End
221907282/221733940 (Hg38)
Orient
-
Location type
Intronic
Target gene
DUSP10
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-98-5p ; hsa-mir-92a-3p ; hsa-mir-129-5p ; hsa-mir-450a-5p ; hsa-mir-4446-5p ; hsa-mir-4755-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6883-3p ; hsa-mir-642b-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-3124-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5088-3p ; hsa-mir-454-5p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-670-3p ; hsa-mir-6818-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-4289 ; hsa-mir-5196-3p ; hsa-mir-7151-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1533321; hsa-mir-1182/Downstream/2523100;
Nearest TSS
ENST00000473358/Upstream/22124; ENST00000421147/Downstream/2960;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/838123, chr1-CpG: 128/Downstream/8192
Upstream sequence
ATGAGGAACAGATAAAGCAAGAACATGGCTGGGAGAGAGAGTTCATTTCTATTATCTGTTCACCTACACTTAAATTAGGAAGCAGGAGAGTGTACCCAAA
Downstream sequence
AGCTCAGAGAGAGGACAGCCAACTAACTGTGCAGCAGTTCAGAAAGAAGTTTCAGGACTTCCTGAAAGACAGGAGCAGGCCATTCAACTCCTTCCCTCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate