Basic Information
VIS ID
TVIS44012428
Fusion event
HTLV-1-PDIA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
10943803/10803677 (Hg38)
End
10943803/10803677 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDIA6
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1909-3p ; hsa-mir-1304-5p ; hsa-mir-543 ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-6864-5p ; hsa-mir-7515 ; hsa-mir-150-5p ; hsa-mir-195-5p ; hsa-mir-218-5p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-3179 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4272 ; hsa-mir-6074 ; hsa-mir-1273d ; hsa-mir-3646 ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-130a-5p ; hsa-mir-23a-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-5705 ; hsa-mir-498 ; hsa-mir-196b-3p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-4274 ; hsa-mir-33a-3p ; hsa-mir-6838-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-376a-5p ; hsa-mir-145-3p ; hsa-mir-4480 ; hsa-mir-5695
Nearest miRNA
hsa-mir-4261/Upstream/611006; hsa-mir-10b/Downstream/736928;
Nearest TSS
ENST00000437798/Upstream/25189; ENST00000418835/Downstream/9077;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/81421, chr2-CpG: 102/Downstream/8599
Upstream sequence
ACACAGTTCTGCCACATTGTGGATCAAGAGCATTTTCATTAGCAACTCTGGAAACTTACATGCAATTTACAACAATAATTTAGGAAAACAAATTCTGAAC
Downstream sequence
TTACTAGTATCTTAAGAACCCAAAAGTTCTCTGAAATGGCATTACTATCAAAATTTCACCTTTTAAATTTACATATACAGTCACATCCACAGggtcaagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate