Basic Information
VIS ID
TVIS44012444
Fusion event
HTLV-1-DNASE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3682588/3632587 (Hg38)
End
3682588/3632587 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNASE1
Nearest miRNA
hsa-mir-1225/Upstream/147118; hsa-mir-11401/Downstream/1038731;
Nearest TSS
ENST00000527434/Upstream/20859; ENST00000570761/Downstream/10293;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/20813, chr16-CpG: 38/Downstream/41756
Nearby gene
DNASE1(+20352) ;
Upstream sequence
cttgctctgaagtctgctctgcctgaaattagtatagccactgggactttctttttgattcctgctatgtctttttccatctctttaattttttctctct
Downstream sequence
tttttttttttttaaagacgagagtttcactcttgttgcccaggctggagtgcagtagcttgatctcagctccctgcaacctccaactcctgggttcaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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