Basic Information
VIS ID
TVIS44012445
Fusion event
HTLV-1-ACSM2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
20494302/20482980 (Hg38)
End
20494302/20482980 (Hg38)
Orient
+
Location type
Intronic
Target gene
ACSM2A
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-3184-3p ; hsa-mir-6818-3p ; hsa-mir-6888-3p ; hsa-mir-6873-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3120-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3615 ; hsa-mir-6812-3p ; hsa-mir-216b-5p ; hsa-mir-6807-5p ; hsa-mir-8055 ; hsa-mir-6844 ; hsa-mir-3191-5p ; hsa-mir-6758-3p ; hsa-mir-5571-5p ; hsa-mir-4742-3p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-218-2-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-4320 ; hsa-mir-4797-5p ; hsa-mir-526b-5p ; hsa-mir-6847-5p
Nearest miRNA
hsa-mir-1225/Upstream/1988404; hsa-mir-11401/Downstream/1023069;
Nearest TSS
ENST00000527434/Upstream/710; ENST00000562852/Downstream/58336;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/133804, chr16-CpG: 65/Downstream/258344
Upstream sequence
GAGAGAGCTGTAACCTCATTCATGTCCCCAGTTTTCTCCTTTTCCCTTGACCTGGATCACCGGGGGTGCAAATGAGGAGATACAAGGGTGATGGAAGTCT
Downstream sequence
TAATGCCAATTTCACATTATTCCAGGAGATGACTACACACTCTAATCCCTTCTCTCTGGCCTTCATCTTTTTTGCAGGTGGTGAAGGCATTTGTGGTCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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