Basic Information
VIS ID
TVIS44012449
Fusion event
HTLV-1-LOC285638 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
108647833/109312132 (Hg38)
End
108647833/109312132 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
LOC285638
Nearest miRNA
hsa-mir-10397/Upstream/8495567; hsa-mir-103a-1/Downstream/1201697;
Nearest TSS
ENST00000502646/Upstream/134615; ENST00000509496/Downstream/14237;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/562630, chr5-CpG: 61/Downstream/97093
Nearby gene
PJA2(-22577) ;
Upstream sequence
TGCAAGCAACAGGACTATAACATACACCTCTTGAAGCTAAGTCATTGGCTTTACAAATCCACTATTGCTGCTTATATGTTTTATGGCTGTGATTGGGAAG
Downstream sequence
CTCCCAACCCCCACAAGTACAGTAGCTTAAATAAACATTTTTCTCTCACATGTTATTACAGAATTCAGTGTCTGTCAGTCAGAAAGTGATGTCCATCCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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