Basic Information
VIS ID
TVIS44012461
Fusion event
HTLV-1-RB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
48980030/48405894 (Hg38)
End
48980030/48405894 (Hg38)
Orient
-
Location type
Intronic
Target gene
RB1
miRNAs that regulate target gene
hsa-mir-106a-5p ; hsa-mir-26a-5p ; hsa-mir-23b-3p ; hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-675-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-192-5p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-221-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-892a ; hsa-mir-3152-3p ; hsa-mir-4318 ; hsa-mir-4325 ; hsa-mir-3614-5p ; hsa-mir-4693-5p ; hsa-mir-6513-5p ; hsa-mir-26b-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-1258 ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-494-3p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-141-3p ; hsa-mir-590-5p
Nearest miRNA
hsa-mir-2276/Upstream/4209694; hsa-mir-1267/Downstream/1590521;
Nearest TSS
ENST00000623511/Upstream/14363; ENST00000480491/Downstream/815;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/86173, chr13-CpG: 96/Downstream/126381
Nearest cancer related gene
RB1(TSG, No orient, 0)
Upstream sequence
tgttttttggtttatctttcctgtgtttctttttataaaaataagcaggtatgcacgttttattttgcctttttcttatacaaaaggtggcatactatgt
Downstream sequence
gtgctcttttatgctttttttcatttaacactaccttcttgaagtcattccatatcaatttatagagatatttctcattattacagctgcatagtactgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate