Basic Information
VIS ID
TVIS44012471
Fusion event
HTLV-1-LOC105372821 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
44598957/43178847 (Hg38)
End
44598957/43178847 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372821
Nearest miRNA
hsa-let-7c/Upstream/227833; hsa-mir-6070/Downstream/431040;
Nearest TSS
ENST00000624081/Upstream/8620; ENST00000435702/Downstream/153192;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/5314, chr21-CpG: 46/Downstream/119858
Nearby gene
CRYAA(+6037) ;
Upstream sequence
TAAAAGGCAGCGGCTGCCCTTGGAGGAGCTGGTGGCTGACTTATTTCTGACAGCCGGTAATGGCCAAGTGCTGGGCCTTTGATTGTACGGGGCTGGGCTG
Downstream sequence
CACTCCACACAGGAGCTGGCTCAGGGGTCCTGCTGGCAGCTGCAGTGCTCTTACCTGCTCGGTGATGAGAAACCCAATTAAGTAAGTGGCCTGCAGCCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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