Basic Information
VIS ID
TVIS44012511
Fusion event
HTLV-1-CCSER1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
91780720/90859569 (Hg38)
End
91780720/90859569 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
CCSER1
miRNAs that regulate target gene
hsa-mir-544a
Nearest miRNA
hsa-mir-12113/Upstream/3558986; hsa-mir-1243/Downstream/8137818;
Nearest TSS
ENST00000502981/Upstream/43756; ENST00000505511/Downstream/253221;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/20453, chr4-CpG: 26/Downstream/1322897
Upstream sequence
TCAAGGAATTCTGGCTTATGTAATTACCGGGCATGTATTTAATTGTTTTCCTTGGAATACTTGTTTATAGGATGATAGAATTAAAAAATAATTGAATCCT
Downstream sequence
AAAATCTGAACTTCAAATTTCTATTTCTCTCTGATATTATGATTAATATAGCTATTTATTTGCAACAGTTCTCAGATCATTGTTTTTCTTTATAAGACAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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