Basic Information
VIS ID
TVIS44012517
Fusion event
HTLV-1-AK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
4713863/4713863 (Hg38)
End
4713863/4713863 (Hg38)
Orient
-
Location type
Intronic
Target gene
AK3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-24-3p ; hsa-mir-324-5p ; hsa-mir-197-3p ; hsa-mir-122-5p ; hsa-mir-143-5p ; hsa-mir-2276-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4287 ; hsa-mir-4430 ; hsa-mir-4469 ; hsa-mir-4685-3p ; hsa-mir-4695-3p ; hsa-mir-504-3p ; hsa-mir-564 ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-642a-5p ; hsa-mir-6499-3p ; hsa-mir-6787-3p ; hsa-mir-6867-3p ; hsa-mir-6892-3p ; hsa-mir-7113-3p ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-1302-9/Upstream/4683582; hsa-let-7a-1/Downstream/136434;
Nearest TSS
ENST00000422679/Upstream/34148; ENST00000381732/Downstream/27364;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/33864, chr9-CpG: 121/Downstream/26831
Upstream sequence
TTACTCCAGTTTCCTGTGGATAACATGGTGAAGAGTGAGATCAGAATCCTGGGGGTGCTTTTCAAGCCACACAGATTCCCTCCAAAGATTCTGGCCTTCC
Downstream sequence
TCTTGCTAATACCCGTCCTCTAGCCcatgcgtacacctacgcctacacatatacacctccacatatacacacctccacatatacacgcctacacatatac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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