Basic Information
VIS ID
TVIS44012519
Fusion event
HTLV-1-LILRB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54783926/54280071 (Hg38)
End
54783926/54280071 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA19A
Target gene
LILRB2
miRNAs that regulate target gene
hsa-mir-4789-5p ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-377-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-7975 ; hsa-mir-5571-3p ; hsa-mir-138-1-3p ; hsa-mir-937-5p ; hsa-mir-3191-5p ; hsa-mir-5702 ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-10b-3p ; hsa-mir-1252-3p ; hsa-mir-3662
Nearest miRNA
hsa-let-7e/Upstream/297674; hsa-mir-10394/Downstream/2038;
Nearest TSS
ENST00000633603/Upstream/1527; ENST00000462769/Downstream/390;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/72564, chr19-CpG: 54/Downstream/135158
Upstream sequence
GTACTCCTGGGCTTCAAGGCTCCCCTGACAACTGAGGGTGACGGGACTCCCCTGGGTGATCACAGAGTCTGGCTCAGCCCACAGGGTGGGCTTGGGAATG
Downstream sequence
GTCCCTGGAAGGAAATCAAAGGTCAGATTCGAAGTCATTTCCCACCCAACAGATCTCAGCTCTCAGCCCAGGACCCTCCAGATGCCCCCATCAGTCAGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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