Basic Information
VIS ID
TVIS44012521
Fusion event
HTLV-1-BBS9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
33649754/33610142 (Hg38)
End
33649754/33610142 (Hg38)
Orient
-
Location type
Intronic
Target gene
BBS9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4709-3p ; hsa-mir-3185 ; hsa-mir-3124-3p ; hsa-mir-676-5p ; hsa-mir-3121-5p ; hsa-mir-1264 ; hsa-mir-6875-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4778-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-1248 ; hsa-mir-5088-3p ; hsa-mir-28-3p ; hsa-mir-8084 ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-1183/Upstream/877065; hsa-mir-10399/Downstream/1330618;
Nearest TSS
ENST00000635602/Upstream/76455; ENST00000311067/Downstream/115839;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/480511, chr7-CpG: 153/Downstream/293911
Nearby gene
BBS9(+4074) ;
Upstream sequence
ttcaaattgtgcaaaagcatatgaccatacacctgggcaaggaactgccctgaagtttaagcctgattagcatcacagtaaatctgTTTATAACAGGAGA
Downstream sequence
GAGTGAGCGAGCGAGATAGAGAGAGAGAATAGAAACTACACTTTAAATTATTGGTTTGTTAATTTCCTCCATGGTTGAAATAACTCCAAAATATGTATGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate