Basic Information
VIS ID
TVIS44012534
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
82491663/80731907 (Hg38)
End
82491663/80731907 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-1265/Upstream/5179354; hsa-mir-107/Downstream/5532787;
Nearest TSS
ENST00000439456/Upstream/82110; ENST00000404547/Downstream/1143407;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/195471, chr10-CpG: 149/Downstream/1142386
Nearby gene
SH2D4B(+85347) ;
Upstream sequence
CACTTGAAAGAGTTTTCTCCCAATTACTGTGTGAATACTAAAGAAATTATACAAAAACAGTAGTCAGGAAATTTCCCCCCAAATAATGTAATTGACTATG
Downstream sequence
TTTCTGTTTCTGAAAACAAGAACATTTGGGAGAACTTTTCTAACTATAGTTCTGATGAAAGATTGATCCCTTGTCTCATGACCTCTCtttttctcttttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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