Basic Information
VIS ID
TVIS44012537
Fusion event
HTLV-1-NELL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
21208110/21186564 (Hg38)
End
21208110/21186564 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
NELL1
Nearest miRNA
hsa-mir-210/Upstream/1426481; hsa-let-7a-2/Downstream/2232541;
Nearest TSS
ENST00000527297/Upstream/250868; ENST00000534263/Downstream/76006;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/516265, chr11-CpG: 88/Downstream/1006062
Upstream sequence
TCTTGACTGATTTTAGTTTGttcgtctaagacatctctttccatctcttaggatattttaattgctcatctctggaccctctccaaggcttgttaagcct
Downstream sequence
ttattgagctgtggtaaccagagctgcacagttttgtgtcttgacatagtgcagttggtttcaaggaaaggctaatatgtttggtcttatgtccaatatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate