Basic Information
VIS ID
TVIS44012539
Fusion event
HTLV-1-SLC1A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
35350066/35328519 (Hg38)
End
35350066/35328519 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
SLC1A2
miRNAs that regulate target gene
hsa-mir-1324 ; hsa-mir-6776-3p ; hsa-mir-497-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-1910-5p ; hsa-mir-455-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-548as-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-383-3p ; hsa-mir-15a-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4743-5p ; hsa-mir-564 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-3190-5p ; hsa-mir-31-5p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-1343/Upstream/386599; hsa-let-7a-2/Downstream/681579;
Nearest TSS
ENST00000527297/Upstream/11136; ENST00000534165/Downstream/23841;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/189066, chr11-CpG: 143/Downstream/90355
Upstream sequence
tcttatatatgaacttattgatttctcacaataacctcaggagataggtactactatcagcaacttttactgaaggaaaaatgaagtcattgaatggtta
Downstream sequence
agttacttgctcaatgtcacaaaagtaatggatggtagagctaggatttgatccctgtcagtcCTGGACTTGGAAAAACTGGTCAGCCCACTCTCCCTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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