Basic Information
VIS ID
TVIS44012556
Fusion event
HTLV-1-CHP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
41569363/41277165 (Hg38)
End
41569363/41277165 (Hg38)
Orient
+
Location type
Intronic
Target gene
CHP1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-144-3p ; hsa-mir-3133 ; hsa-mir-4476 ; hsa-mir-4524b-3p ; hsa-mir-4781-3p ; hsa-mir-567 ; hsa-mir-6077 ; hsa-mir-6079 ; hsa-mir-6828-5p ; hsa-mir-6876-5p ; hsa-mir-7-5p ; hsa-mir-8065 ; hsa-mir-9500 ; hsa-mir-1273g-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3612 ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4257 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4793-3p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-6840-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/4304264; hsa-mir-10393/Downstream/414420;
Nearest TSS
ENST00000557528/Upstream/20255; ENST00000559659/Downstream/55322;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/45631, chr15-CpG: 51/Downstream/6678
Upstream sequence
ttacatcattgcctagaTGAGAAGATAAAGGTTTCAGCCTTTTAGCTGTTACTTAGTCACATGATGGtaaagatggggatacattctgagatatgcaatg
Downstream sequence
ttaggcaattttgtagttgtaggaacatcatagaatgtacctacatgaacctagatggtatagcctactacacacctaggctatgtggtgtggcctattg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate