Basic Information
VIS ID
TVIS44012559
Fusion event
HTLV-1-AKAP13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
85944652/85401421 (Hg38)
End
85944652/85401421 (Hg38)
Orient
+
Location type
Intronic
Target gene
AKAP13
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-16-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-6778-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1281 ; hsa-mir-3667-3p ; hsa-mir-6832-3p ; hsa-mir-183-5p
Nearest miRNA
hsa-mir-10393/Upstream/20759; hsa-mir-11181/Downstream/369075;
Nearest TSS
ENST00000557528/Upstream/20665; ENST00000558811/Downstream/142619;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/19972, chr15-CpG: 20/Downstream/357297
Nearest cancer related gene
AKAP13(OG, No orient, 0)
Upstream sequence
GAAGTCTAGATGTTACTTGGTTTTGGTAAGGAACCCTATGTAGAATTTTGAGGACGTCTCCTCTGCCAACCTGAATTGATCAGAATTTTTATAGACCTCC
Downstream sequence
CAAAGGACCTCTGTTTTGGAAATCTTTTGGGGCAAGGCCAGCTTTGATTTGTTTTCTCTGTTACAACAGCATTATTTGGGCTTAAATCTCAGAAGTGTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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