Basic Information
VIS ID
TVIS44012586
Fusion event
HTLV-1-LOC112268281 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17323413/15951093 (Hg38)
End
17323413/15951093 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
LOC112268281
Nearest miRNA
hsa-mir-10396a/Upstream/2226819; hsa-let-7c/Downstream/587996;
Nearest TSS
ENST00000624081/Upstream/22797; ENST00000602935/Downstream/119429;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/220609, chr21-CpG: 138/Downstream/1561395
Nearby gene
USP25(+71023) ;
Upstream sequence
ttatattctgagactttgctgaaattgattatcagcttaatgagtttttgcgctgagacaatggggtttttaaactatacaatcatgtcatctgcaaaca
Downstream sequence
gagataatttgactccctctcctcctatttgaataccttcatttctttctcttgcctgattgccctggccagaacttccattactatgttgaatgggagt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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