Basic Information
VIS ID
TVIS44012587
Fusion event
HTLV-1-GGT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
24991562/24595595 (Hg38)
End
24991562/24595595 (Hg38)
Orient
+
Location type
Intronic
Target gene
GGT1
Nearest miRNA
hsa-mir-1286/Upstream/1709216; hsa-let-7a-3/Downstream/860051;
Nearest TSS
ENST00000624155/Upstream/781; ENST00000438643/Downstream/7552;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2283, chr22-CpG: 28/Downstream/63540
Upstream sequence
TTGTCCTCTCAGTTCCCGGGGCTGATGTGGAAGCTCAAGGGCTTGCCCTGGATTCTTCAGGGTAGCCCTGCCATCCCTAGTGAGTCAGTGAGTTGGGAGG
Downstream sequence
TTGGGGGCTGGAGAATCAGGTAGGGAGGACACAGCTAGACCTCAGGCCCTGATGGGAACGTACTAGGCTCCAAGTGGGACCTGCCAGGAGACAAGAATTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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