Basic Information
VIS ID
TVIS44012605
Fusion event
HTLV-1-DNAH5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
13860173/13860064 (Hg38)
End
13860173/13860064 (Hg38)
Orient
-
Location type
Intronic
Target gene
DNAH5
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-10397/Upstream/3381919; hsa-mir-103a-1/Downstream/965865;
Nearest TSS
ENST00000502646/Upstream/49541; ENST00000503244/Downstream/239;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/49840, chr5-CpG: 48/Downstream/151446
Upstream sequence
AGTCTCTGGTTTTTCATATAATATGGAGCTTTTATAGAACCATCAGTGGGGACCAGACAACTAATTCAATCTTCAAATATGATAACACCTGGACTCTCTC
Downstream sequence
CTTAGCCTCCCCTTTTCTGAGTCTCTTTCTAACTTCCCACGCACCTGTGTCCAACCCACTCATGTTTGATGTACATGTGTGCAAGATTACTGCCTCTTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate