Basic Information
VIS ID
TVIS44012621
Fusion event
HTLV-1-KBTBD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
32907828/32868216 (Hg38)
End
32907828/32868216 (Hg38)
Orient
-
Location type
UTR3
Target gene
KBTBD2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-151a-3p ; hsa-mir-130b-3p ; hsa-mir-218-5p ; hsa-mir-3591-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-143-5p ; hsa-mir-4255 ; hsa-mir-6757-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-142-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-302a-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p
Nearest miRNA
hsa-mir-1183/Upstream/135139; hsa-mir-10399/Downstream/2072544;
Nearest TSS
ENST00000635602/Upstream/22822; ENST00000464334/Downstream/11277;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/105856, chr7-CpG: 128/Downstream/22902
Upstream sequence
AGCAAAATCAAAATTTAAAAAGCAGACCATTCCCATAACAAAAGAAAAATAGATATTGaatatatacaatttatttaataaattaatGTCATTCAAAATA
Downstream sequence
CAGTGCCAGAACATGGTGCAGTTGAACATGCTAGTAATGTTTGTCATGAAGCACCTGTGCTCATGTTAGATTGGCGGCGCCCCACTACTGCTAGTGGTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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