Basic Information
VIS ID
TVIS44012622
Fusion event
HTLV-1-ASB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
95148956/95519644 (Hg38)
End
95148956/95519644 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASB4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6869-5p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p
Nearest miRNA
hsa-mir-10525/Upstream/1802639; hsa-mir-10399/Downstream/700018;
Nearest TSS
ENST00000635602/Upstream/33743; ENST00000416502/Downstream/67901;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/84547, chr7-CpG: 15/Downstream/8210
Upstream sequence
GTCAAGGTGATGAGAGCAAGTGTAAACCAACATGGATCAAACATCTCAGATAAAATAAACAACTAATGAGGATTCTGGACTTCTACCTGAAGTTATAGTA
Downstream sequence
AATGGAACCGAATTCCTTCTCAAATCCTTACGAATAAACCATGATAATATTTTCTCCATGGTCTTTCTGACCTGTCTTAATACCTTTTCTAAGAAAAGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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