Basic Information
VIS ID
TVIS44012645
Fusion event
HTLV-1-ADAMTSL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
18051499/18051501 (Hg38)
End
18051499/18051501 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9G
Target gene
ADAMTSL1
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-25-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4533 ; hsa-mir-6079 ; hsa-mir-6086 ; hsa-mir-6133 ; hsa-mir-6134 ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-101-2/Upstream/12043597; hsa-let-7a-1/Downstream/521805;
Nearest TSS
ENST00000422679/Upstream/144938; ENST00000431052/Downstream/310719;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/144011, chr9-CpG: 20/Downstream/387057
Nearby gene
SH3GL2(+254373) ;
Upstream sequence
ATGAAGGGGAAGGTAGGAATACTTGGAATATTTGTTGGACATTTCAGAGGCATGTGTCCTGTTGGGCTATATGGTATCAGCCCCTAAAGTTGGGTCCTCC
Downstream sequence
TCAGAGAAGGAGAAAAAAGGAAAGATACAGACAACtttttaaaacttttttttttttttttaaataCAAGGAACTCCAAGATTAAGTGGGTATTCTGCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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