Basic Information
VIS ID
TVIS44012651
Fusion event
HTLV-1-DPH6-DT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4683163/4683151 (Hg38)
End
4683163/4683151 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA19B
Target gene
DPH6-DT
Nearest miRNA
hsa-mir-1227/Upstream/237103; hsa-let-7e/Downstream/87519;
Nearest TSS
ENST00000633603/Upstream/3869; ENST00000591008/Downstream/1659;
Nearest CpG islands
chr19-CpG: 61/Target, None/Upstream, None/Downstream
Upstream sequence
GCGGCCCCTCCCCGCCGCCGCAGAGGGCCGGGTCCCACTGCCCGTCTGCCTCCTCCTCCTCCTCATCGCCGCCGCCCCGCAGTGCCCTGACTGCCGCCGG
Downstream sequence
CCTGGGGCCCCCCCGCCGCTCTGCACACCATGCCCCACCTCTGCCCATCCGAGGCCGGGGTCCCGGGCTCAGCCTCCCACAGAGAGCTGCTGGCGGGGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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