Basic Information
VIS ID
TVIS44012653
Fusion event
HTLV-1-EBF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
158157434/158730426 (Hg38)
End
158157434/158730426 (Hg38)
Orient
-
Location type
Intronic
Target gene
EBF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-129-5p ; hsa-mir-2681-5p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-10397/Upstream/3900886; hsa-mir-103a-1/Downstream/1743976;
Nearest TSS
ENST00000502646/Upstream/22417; ENST00000522582/Downstream/109697;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/871180, chr5-CpG: 25/Downstream/320944
Upstream sequence
GGGATTCTCTCCCACATAAAGCCCAAGTTCCTCAGGTACAGGGATGGGGATATCCCAAACATTCACAACAGGTATGCAATAGTCAATAAAGGTCAGTTTC
Downstream sequence
CTTCTTTCTGCACTGGCAATTAATGATGTATTGGTGACATATATGACTCTGTCTTGAATTTTTGTTTAATTTCTCTCATATTTGTGCCTATTTTCCCAAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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