Basic Information
VIS ID
TVIS44012679
Fusion event
HTLV-1-ANKRD13B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
27940733/29613715 (Hg38)
End
27940733/29613715 (Hg38)
Orient
+
Location type
UTR3
Target gene
ANKRD13B
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-505-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-92a-2-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-608 ; hsa-mir-1275 ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-4651 ; hsa-mir-4665-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6858-5p ; hsa-mir-6779-5p ; hsa-mir-6089 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-185-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-203a-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-4505 ; hsa-mir-5787
Nearest miRNA
hsa-mir-1180/Upstream/222985; hsa-mir-10226/Downstream/503364;
Nearest TSS
ENST00000595228/Upstream/1251; ENST00000581240/Downstream/3754;
Nearest CpG islands
chr17-CpG: 129/Target, None/Upstream, None/Downstream
Upstream sequence
GCGCCACGCCCAGGGCCAGGAGCCAGACAAACCCCGGCCTGCGCGCCTGCAGAGCGGCGGCTGGAGACTGGAGCCACCGCCTCGCGGGTGCAGCAGCACA
Downstream sequence
GCAGGCACGGTTCGGGGAGGGATTCGGCATGGCCGCGGGGTACCTTCCCAGGCCAGGGCCCTGGAGGCAACTGGCACGGCCTGGTCCCCCTGCTTTGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate