Basic Information
VIS ID
TVIS44012697
Fusion event
HTLV-1-ANKRD6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
90173422/89463703 (Hg38)
End
90173422/89463703 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6G
Target gene
ANKRD6
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-653-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-1264
Nearest miRNA
hsa-mir-10398/Upstream/10924394; hsa-mir-1202/Downstream/849039;
Nearest TSS
ENST00000381078/Upstream/30490; ENST00000520458/Downstream/19700;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29787, chr6-CpG: 40/Downstream/174745
Upstream sequence
tatggtgcgatcttggcccactgcaacctccgcctcctgggttcaagcaattctcctgcctcagcctcccgagtagctgggattacaggtgcccgccacc
Downstream sequence
atgcccagctaatttctttgtatttttagtagagatggggcttcaccatgtctggcaggctgttcttgaactcctgacctcaggtgatctgcccgccttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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