Basic Information
VIS ID
TVIS44012712
Fusion event
HTLV-1-FMN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
240333648/240170348 (Hg38)
End
240333648/240170348 (Hg38)
Orient
+
Location type
Intronic
Target gene
FMN2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4738-3p ; hsa-mir-374c-3p ; hsa-mir-4282
Nearest miRNA
hsa-mir-101-1/Upstream/2699157; hsa-mir-3123/Downstream/961924;
Nearest TSS
ENST00000473358/Upstream/78468; ENST00000441342/Downstream/9296;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/76585, chr1-CpG: 48/Downstream/37211
Upstream sequence
TGGCACCCCTAAAGGCTCGTGAAGTTTGAATCAAGATCATTGCCACTGCAGTTTGCCATACCAATGCCTATACCCTGAGCAGAGCTGATCCTGAGGGTTG
Downstream sequence
TTTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGGAAGTGTTGGTGAGGGAGTTGCTAAGCTGAAGGCGGGTGATAACTGTCATCCCATTTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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