Basic Information
VIS ID
TVIS44012735
Fusion event
HTLV-1-BCAS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
52585508/53968969 (Hg38)
End
52585508/53968969 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCAS1
miRNAs that regulate target gene
hsa-mir-4756-3p ; hsa-mir-4330 ; hsa-mir-3919 ; hsa-mir-330-3p ; hsa-mir-3123 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-933 ; hsa-mir-3650
Nearest miRNA
hsa-mir-103a-2/Upstream/2515992; hsa-mir-1-1/Downstream/99439;
Nearest TSS
ENST00000382410/Upstream/28809; ENST00000474326/Downstream/26960;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/308457, chr20-CpG: 136/Downstream/203744
Upstream sequence
TGCTGGGCTGTTGGCTTTGGACCCCAATCTATCTTTAGGAAACGAGGTGGAGACTGGAGCCATATCAGAGACTGAGAATGGCAATAGAGCATGGACATGG
Downstream sequence
ATTTCCACATTTTGAACTGATTTAATTCAATCGCATTTCCGAAAAGTAAGTGTGAGCCACAAGAGCCCTTCAGGTGAGGCTGAAATATAGGcaatctaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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