Basic Information
VIS ID
TVIS44012748
Fusion event
HTLV-1-SPIDR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
48348040/47435478 (Hg38)
End
48348040/47435478 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPIDR
miRNAs that regulate target gene
hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-197-3p ; hsa-mir-6841-3p ; hsa-mir-4691-3p ; hsa-mir-3613-3p ; hsa-mir-4282
Nearest miRNA
hsa-mir-124-1/Upstream/4539203; hsa-mir-10400/Downstream/14279310;
Nearest TSS
ENST00000518652/Upstream/27617; ENST00000518692/Downstream/4923;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/173979, chr8-CpG: 229/Downstream/301726
Upstream sequence
GACTTTTCAAAGAGCAGTTAGCTGATTAAATAACGAATTCATGCAGTTATTCAGCAAATGTTGTTATTCTTGAAGTTGAATACTGTCCATTTTTAACTAA
Downstream sequence
GAATTATGTTTCATCTGCTAGGCATATGCATGGATAGAAATTACTAGATCTCTTGGTGTATCTTCTTCATTGAATCTTTCTGTTCCTGTTTCTTAATCGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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