Basic Information
VIS ID
TVIS44012753
Fusion event
HTLV-1-UBL4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153712411/154484072 (Hg38)
End
153712411/154484072 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRAXE ; FRAXF
Target gene
UBL4A
miRNAs that regulate target gene
hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-6834-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-548au-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-3194-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-6868-5p ; hsa-mir-3128 ; hsa-mir-132-5p ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4739 ; hsa-mir-8057 ; hsa-mir-760 ; hsa-mir-6822-3p ; hsa-mir-4786-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-942-3p ; hsa-mir-4802-3p
Nearest miRNA
hsa-let-7f-2/Upstream/33686; hsa-mir-1184-1/Downstream/284524;
Nearest TSS
ENST00000429181/Upstream/4815; ENST00000492469/Downstream/2030;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/4595, chrX-CpG: 119/Downstream/1877
Upstream sequence
TTCCGTTAACTGATTAAACAAATTGCCTTTATTGTTAAACCAATGATTGGATATCAGAAACAGCCTAGCTAATATAGCTCCTTTTGGATAAAAGTAGAAG
Downstream sequence
CCTCACATTCACCTTTAATGTTATTTCACTTTTTCCAAAATCAATTTCCTGGCACCACACAAACAAGAACACTGGTAAATGTATCACCTGAACTGCAGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate