Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene169785047169392857169612629169556965169557919169588952
Basic Information
VIS ID
TVIS44012777
Fusion event
HTLV-1-NEK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q33
Reference genome
GRCh37/hg19
Start
170510103/169588952 (Hg38)
End
170510103/169588952 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEK1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-484 ; hsa-mir-302a-5p ; hsa-mir-6507-3p
Nearest miRNA
hsa-mir-12113/Upstream/4202615; hsa-mir-1305/Downstream/1597232;
Nearest TSS
ENST00000502981/Upstream/3453; ENST00000506924/Downstream/10191;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/317259, chr4-CpG: 55/Downstream/23295
Upstream sequence
cactgaaaaattcctatcacctagtgacacggtgactgacatacactgtagagcaattactttattttttaataaatttagtatagccgaagtgtacagt
Downstream sequence
gtttataaactctacagtagcatacagaaatgtgctaggtcttcacattcactcaccactcactcactcacagaaagcaacttccagtccagcaagctcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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