Basic Information
VIS ID
TVIS44012791
Fusion event
HTLV-1-KCTD8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44332134/44330117 (Hg38)
End
44332134/44330117 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCTD8
Nearest miRNA
hsa-mir-12113/Upstream/3827998; hsa-mir-1243/Downstream/3322552;
Nearest TSS
ENST00000502981/Upstream/313055; ENST00000513775/Downstream/117496;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1672584, chr4-CpG: 174/Downstream/117252
Upstream sequence
CCCACTGTATGTTCTATATAGAAAAGCCCCATCAATTCAGAAAAAAAATGCAATGAACATGTCAGCTTTTTCTATTATCATTCTTTTTTTCATTGTAACT
Downstream sequence
AAAAACCTCACATTTCAGGTTAGATACGTTTGAATCTAATTAGGTGGACCTTTTGGTTAGTCTTATAGTCATCAGTAATATGTTGTTAGAATTTCCTATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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