Basic Information
VIS ID
TVIS44012798
Fusion event
HTLV-1-ACTL8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
18118594/17792099 (Hg38)
End
18118594/17792099 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
ACTL8
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-148b-5p ; hsa-mir-186-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-12136/Upstream/514124; hsa-mir-101-1/Downstream/1091103;
Nearest TSS
ENST00000473358/Upstream/36786; ENST00000617065/Downstream/30883;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/94802, chr1-CpG: 31/Downstream/33784
Upstream sequence
CCCTCATCAACCCCATCAGGAACCCTTATCATTGGGGCTGGAGCCAGGGCCTCTTAACCCCAATGGGCCCCTCTCAGTTCAAAGAAGAGGAGCCCCTCTT
Downstream sequence
TGCATCAAAGCACTGTGTGGCTCAGCCAGGTCAGGACAGCTGCCCCAGGTGGAGCTCAAGAAAGGGTGGACCAGGCGCttattaggctcttgcagtaggc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate