Basic Information
VIS ID
TVIS44012801
Fusion event
HTLV-1-TDRD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
61138925/60564791 (Hg38)
End
61138925/60564791 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
TDRD3
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-1297/Upstream/5390243; hsa-mir-1267/Downstream/635007;
Nearest TSS
ENST00000623511/Upstream/35828; ENST00000413402/Downstream/120408;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/166880, chr13-CpG: 36/Downstream/3246795
Upstream sequence
TTTAAAAAATGTTTGTAAACTATGAAATTAAAATTATTTTTTTGAGTTGTAAATCTCTTACAGAGTACTGAGACCTAAAGGAAGAAGATAGGCTAGAAGA
Downstream sequence
GGAATAAAGTATAAATTTCATTCAAAGATGACTGAAAATAAACTGATCTATTAAATCAAGCTGTGTGTTAAATAAAGAGGAAAGAAGTACCCATTCTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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