Basic Information
VIS ID
TVIS44012807
Fusion event
HTLV-1-GYPC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
127417010/126659434 (Hg38)
End
127417010/126659434 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
GYPC
Nearest miRNA
hsa-mir-1285-2/Upstream/12938066; hsa-mir-10b/Downstream/764103;
Nearest TSS
ENST00000437798/Upstream/3245; ENST00000437793/Downstream/239430;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2839, chr2-CpG: 36/Downstream/117722
Upstream sequence
catgtcctcatcacatgacgagtgaggggcagagcagaggccagagcaacatccgtgctgtggagtcagccctgggtttgactgccctccaatgttcacc
Downstream sequence
agctttgggagagagaggaaatacctcagcacctcagttttcccatctgtgagtgggaatgataacagccacttccccagagtCACCCGAAGAGCAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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