Basic Information
VIS ID
TVIS44012814
Fusion event
HTLV-1-IFT74 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
26969369/26969371 (Hg38)
End
26969369/26969371 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
IFT74
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-101-2/Upstream/5457186; hsa-let-7a-1/Downstream/1894255;
Nearest TSS
ENST00000422679/Upstream/12892; ENST00000494236/Downstream/7196;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/12599, chr9-CpG: 27/Downstream/558988
Upstream sequence
tatatttaggattgttgtatctcttgcttaattgattcctttattattatgtaattatcttcttgtctttttttttaaactgtttttgatttgaagatgt
Downstream sequence
atgtatagctactcctgcttgcttttggtagtgtggaataccttttcccactcttttgtttttagcctatgtgtgtcttttagggcttgatacgtttctc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate